Pedro A Valdes Hernandez, Ph.D.
Assistant Professor
Department:
DN-COMMUNITY DENTISTRY
Business Phone:
(352) 294-5984
Business Email:
pvaldeshernandez@dental.ufl.edu
Accomplishments
Top Reviewer
2024
·
The Journal of Pain
Teaching Profile
Courses Taught
2024
DEN6001 Intr Evdnce Dent Prac
Research Profile
Dr Valdes-Hernandez’s field of expertise is Neuroimaging. He specializes in Medical Image Analysis, Biostatistics, Computational Neuroanatomy, Computational Neurosciences and the principles of Magnetic Resonance Imaging. His work has been focused on 1) the analysis of large multimodal neuroimaging databases [e.g., MRI, (anatomical, functional, diffusion), and brain electrical topographies and tomographies based on EEG and MEG], 2) the theoretical modeling of brain activity and signal/image formation, and 3) experimental testing of several biophysical theories of the brain. Over his career, He has used a great amount of programming (e.g., MATLAB and Python) to apply several statistical methods (e.g., multivariate regression, machine learning algorithms, signal processing, and inference of state-space models) to extract information from multimodal brain images and infer neurobiological processes. He has also performed EEG/fMRI experimentation in both humans and rats. Moreover, with a mindset on the betterment of health and quality of life of society, he has dealt with a variety of different normal and pathological populations covering a wide range of ages (e.g., he has studied children with Epilepsy and older adults with and without chronic pain).
Open Researcher and Contributor ID (ORCID)
0000-0003-2278-0100
Areas of Interest
- Aging
- Artificial Intelligence
- Chronic Pain
- MRI
- Neuroimaging
Publications
Academic Articles
2025
Widespread and prolonged pain may reduce brain clearance capacity only via sleep impairment: Evidence from participants with knee pain
The Journal of Pain.
30
[DOI] 10.1016/j.jpain.2025.105356.
2024
ENIGMA-Chronic Pain: a worldwide initiative to identify brain correlates of chronic pain
Pain.
165(12):2662-2666
[DOI] 10.1097/j.pain.0000000000003317.
[PMID] 39058957.
2024
Interoceptive Accuracy Enhances Deception Detection in Older Adults
The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences.
79(11)
[DOI] 10.1093/geronb/gbae151.
[PMID] 39297532.
2023
Accelerated brain aging mediates the association between psychological profiles and clinical pain in knee osteoarthritis
The Journal of Pain.
[DOI] 10.1016/j.jpain.2023.11.006.
2023
Biological Aging In Those With Chronic Pain; The Role Of Fatigue
The Journal of Pain.
24(4)
[DOI] 10.1016/j.jpain.2023.02.209.
2023
Brain-predicted age difference mediates the association between PROMIS sleep impairment, and self-reported pain measure in persons with knee pain
Aging Brain.
4
[DOI] 10.1016/j.nbas.2023.100088.
[PMID] 37519450.
2023
Feasibility of brain age predictions from clinical T1-weighted MRIs
Brain Research Bulletin.
[DOI] 10.1016/j.brainresbull.2023.110811.
2023
Post-Traumatic Osteoarthritis Does Not Alter Periaqueductal Gray Connectivity In Aged Rats
The Journal of Pain.
24(4)
[DOI] 10.1016/j.jpain.2023.02.224.
2023
Resting-State Functional Connectivity In Persons With Knee Osteoarthritis Pain
The Journal of Pain.
24(4):75-76
[DOI] 10.1016/j.jpain.2023.02.220.
2023
Toward MR protocol-agnostic, unbiased brain age predicted from clinical-grade MRIs
Scientific Reports.
13(1)
[DOI] 10.1038/s41598-023-47021-y.
[PMID] 37950024.
2022
Chronic Musculoskeletal Pain Moderates the Association between Sleep Quality and Dorsostriatal-Sensorimotor Resting State Functional Connectivity in Community-Dwelling Older Adults
The Journal of Pain.
23(5):43-44
[DOI] 10.1016/j.jpain.2022.03.166.
2022
Chronic Musculoskeletal Pain Moderates the Association between Sleep Quality and Dorsostriatal-Sensorimotor Resting State Functional Connectivity in Community-Dwelling Older Adults
Pain Research and Management.
2022:1-12
[DOI] 10.1155/2022/4347759.
[PMID] 35432664.
2022
Clinical vitamin D levels are associated with insular volume and inferior temporal gyrus white matter surface area in community-dwelling individuals with knee pain
Frontiers in Neuroscience.
16
[DOI] 10.3389/fnins.2022.882322.
[PMID] 36117614.
2022
Cross-Sectional Brain-Predicted Age Differences in Community-Dwelling Middle-Aged and Older Adults with High Impact Knee Pain.
Journal of pain research.
15:3575-3587
[DOI] 10.2147/JPR.S384229.
[PMID] 36415658.
2022
Experimental Pain Phenotype Profiles in Community-dwelling Older Adults
The Clinical Journal of Pain.
38(7):451-458
[DOI] 10.1097/ajp.0000000000001048.
2022
Vitamin D Is Associated with Insular Volume and Inferior Temporal Gyrus White Matter Surface Area
The Journal of Pain.
23(5):41-42
[DOI] 10.1016/j.jpain.2022.03.159.
2021
Age Differences in Multimodal Quantitative Sensory Testing and Associations With Brain Volume
Innovation in Aging.
5(3)
[DOI] 10.1093/geroni/igab033.
[PMID] 34616958.
2021
Arterial blood stealing as a mechanism of negative BOLD response: From the steady-flow with nonlinear phase separation to a windkessel-based model
Journal of Theoretical Biology.
529
[DOI] 10.1016/j.jtbi.2021.110856.
[PMID] 34363836.
2021
Chronic oxytocin administration in older men modulates functional connectivity during animacy perception
Aging Brain.
1
[DOI] 10.1016/j.nbas.2021.100023.
2021
Chronic Pain is Associated With Reduced Sympathetic Nervous System Reactivity During Simple and Complex Walking Tasks: Potential Cerebral Mechanisms
Chronic Stress.
5
[DOI] 10.1177/24705470211030273.
[PMID] 34286166.
2021
Identification of Negative BOLD Responses in Epilepsy Using Windkessel Models
Frontiers in Neurology.
12
[DOI] 10.3389/fneur.2021.659081.
[PMID] 34690906.
2021
Psychological profiles in adults with knee OA-related pain: a replication study
Therapeutic Advances in Musculoskeletal Disease.
13
[DOI] 10.1177/1759720×211059614.
2021
Resting-state functional connectivity patterns are associated with worst pain duration in community-dwelling older adults
PAIN Reports.
6(4)
[DOI] 10.1097/pr9.0000000000000978.
2020
Cortical Thickness Mediates the Association Between Self-Reported Pain and Sleep Quality in Community-Dwelling Older Adults
Journal of Pain Research.
Volume 13:2389-2400
[DOI] 10.2147/jpr.s260611.
2020
Modeling functional resting-state brain networks through neural message passing on the human connectome
Neural Networks.
123:52-69
[DOI] 10.1016/j.neunet.2019.11.014.
2019
EECoG-Comp: An Open Source Platform for Concurrent EEG/ECoG Comparisons—Applications to Connectivity Studies
Brain Topography.
32(4):550-568
[DOI] 10.1007/s10548-019-00708-w.
[PMID] 31209695.
2019
Epilepsy Focus Localization in Patients Utilizing BOLD Differences Related to Regional Metabolic Dynamics
Open Journal of Radiology.
09(03):163-175
[DOI] 10.4236/ojrad.2019.93015.
2019
Mapping Brain Activity with Electrocorticography: Resolution Properties and Robustness of Inverse Solutions
Brain Topography.
32(4):583-598
[DOI] 10.1007/s10548-018-0623-1.
2019
Validating Non-invasive EEG Source Imaging Using Optimal Electrode Configurations on a Representative Rat Head Model
Brain Topography.
32(4):599-624
[DOI] 10.1007/s10548-016-0484-4.
2018
Histological Characterization of the Irritative Zones in Focal Cortical Dysplasia Using a Preclinical Rat Model
Frontiers in Cellular Neuroscience.
12
[DOI] 10.3389/fncel.2018.00052.
[PMID] 29867355.
2018
waveCSD: A method for estimating transmembrane currents originated from propagating neuronal activity in the neocortex: Application to study cortical spreading depression
Journal of Neuroscience Methods.
307:106-124
[DOI] 10.1016/j.jneumeth.2018.06.024.
[PMID] 29997062.
2017
Spatio Temporal EEG Source Imaging with the Hierarchical Bayesian Elastic Net and Elitist Lasso Models
Frontiers in Neuroscience.
11
[DOI] 10.3389/fnins.2017.00635.
[PMID] 29200994.
2015
Tensor Analysis and Fusion of Multimodal Brain Images
Proceedings of the IEEE.
103(9):1531-1559
[DOI] 10.1109/jproc.2015.2455028.
2011
An in vivo MRI template set for morphometry, tissue segmentation, and fMRI localization in rats
Frontiers in Neuroinformatics.
5
[DOI] 10.3389/fninf.2011.00026.
[PMID] 22275894.
2011
Automated Discrimination of Brain Pathological State Attending to Complex Structural Brain Network Properties: The Shiverer Mutant Mouse Case
PLoS ONE.
6(5)
[DOI] 10.1371/journal.pone.0019071.
[PMID] 21637753.
2011
Covert face recognition without the fusiform-temporal pathways
NeuroImage.
57(3):1162-1176
[DOI] 10.1016/j.neuroimage.2011.04.057.
2010
White matter architecture rather than cortical surface area correlates with the EEG alpha rhythm
NeuroImage.
49(3):2328-2339
[DOI] 10.1016/j.neuroimage.2009.10.030.
2009
Approximate average head models for EEG source imaging
Journal of Neuroscience Methods.
185(1):125-132
[DOI] 10.1016/j.jneumeth.2009.09.005.
2009
Latin American Brain Mapping Network (LABMAN)
NeuroImage.
47(1):312-313
[DOI] 10.1016/j.neuroimage.2009.03.030.
2009
On the EEG/MEG forward problem solution for distributed cortical sources
Medical & Biological Engineering & Computing.
47(10):1083-1091
[DOI] 10.1007/s11517-009-0529-x.
2008
A Bayesian framework to identify principal intravoxel diffusion profiles based on diffusion-weighted MR imaging
NeuroImage.
42(2):750-770
[DOI] 10.1016/j.neuroimage.2008.04.242.
2007
Characterizing brain anatomical connections using diffusion weighted MRI and graph theory
NeuroImage.
36(3):645-660
[DOI] 10.1016/j.neuroimage.2007.02.012.
Grants
Jun 2024
ACTIVE
Machine learning-based brain aging morphological signatures of chronic musculoskeletal pain
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Contact Details
Phones:
- Business:
- (352) 294-5984
Emails:
- Business:
- pvaldeshernandez@dental.ufl.edu
Addresses:
- Business Mailing:
-
1889 MUSEUM RD FL 7
GAINESVILLE FL 32611 - Business Street:
-
Office 7018
1889 MUSEUM RD FL 7
GAINESVILLE FL 32611